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Respiratory Symptoms From Inhaled Substances

Respiratory Symptoms From Inhaled Substances

Allergens

An allergen is a substance which is capable of initiating an allergic reaction. The most important inhaled allergens are tiny invisible pollen grains, mold spores, house dust and animal danders.

Allergy-causing pollens come from plant flowers which at certain times of the year release large quantities of light buoyant pollen which can be carried for miles by the wind. These flowers are inconspicuous and often don’t really look like blossoms. They include trees which pollinate in spring, grasses in summer, and weeds in the fall. (See OAAC educational material handout Pollen Seasons) Ornamental flowers are generally not very important in allergy. They have large sticky pollen grains that are carried to other flowers by insects. They are not sufficiently abundant in the air to cause symptoms unless an allergic person is very close to them. However, some ornamental flowers are related to weeds. This is why some ragweed-allergic patients have symptoms when they are close to chrysanthemums, zinnias, asters, daisies, etc.

There are many types of molds in our environment. They have varying preferences for the types of places and conditions under which they grow into colonies. Some prefer to colonize indoors, some outdoors. The spores released by colonies are carried through the air to new places suitable for new colony formation. These spores are smaller than pollen grains but like pollens can cause allergic symptoms when they are inhaled.

The important constituents of house dust are the products of microscopic organisms found in most homes. House dust mites and molds thrive in warm moist conditions.

Like humans, fur-bearing animals continually grow new layers of skin. The indoor pet’s “dander” (tiny flakes of the outer layer of skin) falls off, disintegrates, and causes symptoms when inhaled. During early stages of allergy to a pet, patients are often unaware that the animal is contributing to their symptoms.

If a person is allergic to a pet, he/she should strictly avoid the animal. Outdoor pets are not of major concern. Pets that are confined to a limited part of the house (such as a tiled or wood-floored utility room and kitchen) are better then pets that contaminate the entire house. At the very least, pets should be kept out of the allergic person’s bedroom at all times. (See OAAC educational material handout Environmental Controls for Indoor Allergens.)

Irritants

An irritant is a substance which may trigger certain symptoms strictly because of its irritating effects. The symptoms mimic allergy, but in fact they are not really the result of an allergic reaction. Some individuals are extremely sensitive to these inhales substances (which incidentally bother the average person very little). The basis for this extreme membrane sensitivity is not well understood, but it is not allergy.

The most common offenders are smoke, cold air, wind, temperature changes, and weather fronts. Other provoking factors which bother some people in varying degrees include sharp pungent odors (paint, turpentine, aerosol sprays, perfumes, cleansers, cosmetics, chemical odors, exhaust smoke, insecticides, detergents and new fabric odors).

Respiratory infection is included in this category as is external wheezing in asthmatics.

Some substances are not only allergens or irritants but can be both. Examples include house dust, feed and grain dusts, and live Christmas trees. In any given patient allergens, irritants or a combination of both may be of major importance in the production of either asthma or nasal symptoms.

Occasionally patients who are sensitive to both irritants and allergens will have useful reduction in nasal and chest symptoms caused by irritants when their allergies are successfully treated. More commonly their susceptibility to irritants remains a separate problem and the treatment is by appropriate medication and avoidance. Irritant induced symptoms are more difficult to treat than those from allergens.

Recent News

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Important Recall Notice for AIRSUPRA Inhalation Aerosol

AstraZeneca Pharmaceuticals LP, the maker of the inhalation medication AIRSUPRA® (albuterol and budesonide) aerosol, has initiated a voluntary recall for their product. This recall is effective immediately and involves multiple product lots. The recalled inhalers might not work properly.

Reason for Recall:

A defect in the delivery system of these inhalers has been identified, which may hinder the proper administration of the medication needed for effective asthma control.

Product Details:

Product Name: AIRSUPRA (albuterol and budesonide) inhalation aerosol 

Strength: 90 mcg/80 mcg per inhalation 

Packaging Types:

120-inhalation canister (NDC 0310-9080-12) 

 28-inhalation canister (NDC 0310-9080-28) 

Recall Number:  D-0444-2025 

Affected Lot Numbers:

For 120-inhalation canisters: Lots: 6270044C00, 6270040D00, 6270034E00, Exp Date 10/2026; 6270053C00, 6270045C00, 6270047C00, 6270056C00, 6270052C00, 6270063E00 Exp 11/30/2026; 6270064C00, 6270071D00, 6270075D00, 6270075F00 Exp Date 12/31/2026; 6270107C00, Exp Date 9/30/2027  

For 28-inhalation canisters: Lot 6270019E00, Exp Date 7/31/2025; 6270021D00, Exp 8/31/2025; 6270095C00, Exp 2/28/2026

Rx only, Manufactured for: AstraZeneca Pharmaceuticals LP, Wilmington, DE 19850, By: AstraZeneca Dunkerque Production (AZDP), Dunkerque, France, Product of France

What You Should Do:

Patients and users are advised not to use the inhalers associated with the affected lots. Please contact your pharmacy or healthcare provider as soon as possible to discuss alternative treatment options. Contact the dispensing pharmacy or AstraZeneca for return processing information.

If you are a current patient of the Oklahoma Allergy and Asthma Clinic affected by this recall, please give us a call at 405-235-0040.  

Recall Contact Information:

For product questions, to report an adverse event or side effect, or to report a product quality issue, you can contact the AstraZeneca Information Center by phone at:

1-800-236-9933 (M-F, 8AM-6PM ET, excluding holidays)

Or you can report a product quality issue online: https://contactazmedical.astrazeneca.com/content/astrazeneca-champion/global/en/amp-form.html

For more information on this recall, please visit: https://www.accessdata.fda.gov/scripts/ires/?Event=96857

The post Important Recall Notice for AIRSUPRA Inhalation Aerosol appeared first on Oklahoma Allergy and Asthma Clinic.

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