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Allergy Injection Treatment Procedures and Precautions

Allergy Injection Treatment Procedures and Precautions

Method of Administration

Allergy injections are given subcutaneously, half-way between the elbow and the shoulder along the outer aspect of the back of the upper arm, or the outside of the mid-thigh. They should not be given too shallowly in the skin, nor should they ever be given without first aspirating (drawing back on the syringe plunger after the needle is in the tissue). If blood is seen when aspirating, the needle should be withdrawn before injecting and another area should be used for the injection. If there are 2 vials (such as “LEFT” and “RIGHT”), there should be 2 injections each time shots are given unless the doctor instructs otherwise. Some injections will be given from individual numbered unit dose vials while other will be dispensed from a larger multi-dose vial according to instructions specific for an individual patient.

A disposable 1 cc allergy treatment syringe with the ½ or 5/8 inch, 25, 26 or 27 gauge, regular bevel needle should be used to give the injections.

Important Precautions

  • The injections should never be administered unless injectable epinephrine 1:1000 is immediately available and there is a reliable person other than the patient to inject it.
  • OAAC requires that allergy injections be administered by a medically competent person in a medical facility equipped to treat (possible severe) allergic reactions. This advice encompasses all patients – even doctors, nurses, and other health professionals who are allergy patients.
  • Administration of allergy shots outside of an OAAC shot treatment room (for example your physician’s office) must be cleared by your OAAC physician (not just from your primary care physician or other health care provider); please do not proceed without it.

Injection Reactions

Allergy injection treatment is intended to decrease a patient’s sensitivities so that in time he/she will feel better. Injections should not cause allergy symptoms. Whenever problems occur, please discuss it with your OAAC doctor or staff.

A local reaction to an allergy injection consists of redness, soreness, itching, and/or swelling at the injection site. Most allergic individuals can be expected to have some local reaction at times. Some will have moderate local reactions regularly, at least until they have been on treatment for many months.

Should there be an excessive (greater than a quarter or 25 cent piece in diameter and lasting more than 24 hours) local reaction after an injection, an antihistamine (like Benadryl, Claritin, Allegra, Zyrtec or Xyzal), cold compress, and topical steroid cream may be used for symptom relief. Your OAAC physician and staff must be notified of the dose number and of the name of the specific vial before more injections are given. A dosage reduction may be indicated.

Systemic (generalized) anaphylaxis reactions to allergy injections are rare (0.015 to 0.02% of injections administered at OAAC Clinics). However, if they occur, prompt treatment with Epinephrine and not just an antihistamine like Benadryl is vitally important. It could save your life. In the event of a systemic (generalized) reaction after an allergy injection, there may or may not be marked swelling at the injection site, plus a vague feeling of apprehension and itching of the palms followed by generalized hives, flushing, sneezing, nasal congestion, increased mucus production or throat clearing, difficulty breathing, coughing, or wheezing.

PATIENTS MUST WAIT 20-30 MINUTES AFTER AN INJECTION SO THAT THEY MAY BE OBSERVED FOR SIGNS OF A GENERALIZED REACTION.

This type of reaction requires treatment with Epinephrine and not just an antihistamine like Benadryl. Prompt medical attention is always needed. If the shot was given at a location other than an OAAC treatment room your clinic physician must be notified before further allergy injections are given because dosage reduction is mandatory. Your OAAC physician is always notified by staff of systemic reactions which occur at an OAAC treatment room.

Beta blocker drugs may make systemic reactions more difficult to treat and you must notify your OAAC physician if you are taking one.

Recent News

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High Cedar Pollen Levels Return for the Seventh Time in Ten Days

Highest Levels of Tree Pollen Detected in the United States for 2/26/2026

February 26, 2026

A VERY HIGH ALERT has been issued for tree pollen levels in Oklahoma City, marking the SIXTH VERY HIGH ALERT in the last ten days, and the SEVENTH HIGH or VERY HIGH ALERT in that same timeframe. Today’s counts are the highest reported in the U.S. and the second highest recorded this year.

Cedar and Elm (Chinese Elm, also known as Lacebark Elm) pollen counts are both registering in the VERY HIGH range. These counts represent an extreme exposure situation, with severe symptoms expected in pollen-sensitive individuals. Those with allergic bronchial asthma are strongly advised to stay indoors.

Today also marks the FOURTH DAY in the TOP TEN HIGHEST Cedar Season Days in the past five years. For all tree pollen seasons, it ranks as the SEVENTH highest day recorded in 20 years in Oklahoma City.


Cedar Fever and Regional Impact

Cedar tree pollen contributes to “Cedar Fever”, a winter allergy affecting millions across Oklahoma, Texas, Arkansas, and Missouri. Unlike spring and summer allergies, Cedar Fever peaks from late November to February, with pollen grains capable of traveling hundreds of miles in Oklahoma winds.


Recommendations to Reduce Exposure

OAAC allergists recommend the following steps:

  • Limit outdoor activities on high pollen days
  • Keep windows closed at home and in vehicles
  • Change clothes and shower after being outdoors
  • Leave shoes at the door to avoid tracking pollen inside
  • Wash hands frequently, especially after outdoor contact
  • Wear a dust mask for outdoor chores
  • Use and regularly replace HEPA filters in HVAC systems

Medical Management

  • Continuous use of nasal sprays and antihistamines may help, but proper diagnosis is essential
  • Seasonal allergies cannot be diagnosed by history alone. OAAC allergists offer simple tests to identify specific triggers

OAAC serves patients of all ages across the southwest region, with clinics in Edmond, Norman, northwest Oklahoma City, and the OU Health Sciences Center campus.


Contact and Appointment Information

Visit www.oklahomaallergy.com for clinic locations.
To schedule an appointment or request more information, call (405) 235-0040 or visit the website.

The post High Cedar Pollen Levels Return for the Seventh Time in Ten Days appeared first on Oklahoma Allergy and Asthma Clinic.

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